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Updated: May 16, 2026

Functional Imaging of Viral Transcription Factories Using 3D Fluorescence Microscopy
09:03

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Published on: January 18, 2018

Long Non-coding RNAs in Gammaherpesvirus Infections: Their Roles in Tumorigenic Mechanisms

Wen Liu1, Yan Zhang1,2, Bing Luo1

  • 1Department of Pathogenic Biology, School of Basic Medicine, Qingdao University, Qingdao, China.

Frontiers in Microbiology
|February 1, 2021
PubMed

Insights

Long non-coding RNAs (lncRNAs) are involved in virus-triggered cancers. This review covers lncRNAs in Epstein-Barr virus and Kaposi's sarcoma herpesvirus cancers, exploring their roles and potential as biomarkers.

Area of Science:

  • Molecular Biology
  • Oncology
  • Virology

Background:

  • Long non-coding RNAs (lncRNAs) are key regulators of gene expression.
  • Abnormal lncRNA expression is implicated in virus-triggered cancers.
  • Virus-encoded lncRNAs also contribute to tumorigenesis.

Purpose of the Study:

  • To review lncRNAs in Epstein-Barr virus (EBV) and Kaposi's sarcoma herpesvirus (KSHV) associated cancers.
  • To elucidate the functions and mechanisms of lncRNAs in these viral oncogenesis.
  • To discuss the potential of lncRNAs as biomarkers and therapeutic targets.

Main Methods:

  • Literature review of studies on lncRNAs in EBV and KSHV-driven tumors.
  • Analysis of lncRNA roles in tumor initiation, progression, and metastasis.
  • Examination of lncRNA involvement in critical cellular signaling pathways.

Main Results:

  • lncRNAs play significant roles in the occurrence, development, invasion, and metastasis of EBV and KSHV-induced cancers.
  • Specific lncRNAs are identified as crucial players in oncogenic signaling pathways.
  • lncRNAs demonstrate potential as diagnostic and therapeutic targets.

Conclusions:

  • lncRNAs are critical mediators in viral oncogenesis, particularly for EBV and KSHV.
  • Understanding lncRNA functions offers new avenues for cancer diagnostics and treatment.
  • Further research into lncRNAs could lead to novel therapeutic strategies for viral cancers.
Keywords:
Epstein–Barr virusKSHVgammaherpesviruslncRNAtumorigenesis

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