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Relationship between serum Dickkopf-1 and albuminuria in patients with type 2 diabetes

Ning-Ning Hou1, Cheng-Xia Kan1, Na Huang1

  • 1Department of Endocrinology, Affiliated Hospital of Weifang Medical University, Weifang 261031, Shandong Province, China.

World Journal of Diabetes
|February 1, 2021
PubMed
Abstract

Insights

Lower serum Dickkopf-1 levels are linked to albuminuria in type 2 diabetes patients. This finding suggests Dickkopf-1 may be a risk factor for diabetic kidney disease progression.

Area of Science:

  • Nephrology
  • Endocrinology
  • Molecular Biology

Background:

  • Diabetic kidney disease (DKD) is a serious complication of diabetes.
  • Wingless (Wnt) signaling pathway dysregulation contributes to renal fibrosis in DKD.
  • Dickkopf-1 (DKK1), a Wnt inhibitor, plays roles in fibrosis, metabolism, and inflammation, but its association with DKD is unclear.

Purpose of the Study:

  • To investigate the relationship between serum Dickkopf-1 levels and albuminuria in type 2 diabetes (T2D).

Main Methods:

  • A case-control study involving 73 T2D patients and 24 healthy controls.
  • T2D patients were categorized by urinary albumin/creatinine ratio (UACR) into normal, microalbuminuria, and macroalbuminuria groups.
  • Serum DKK1 levels were measured using ELISA; clinical and metabolic data were collected.

Main Results:

  • Serum DKK1 levels were not significantly different between healthy individuals and the normal albuminuria group.
  • DKK1 levels were significantly lower in microalbuminuria and macroalbuminuria groups compared to the normal albuminuria group.
  • Serum DKK1 levels were independently associated with UACR (OR=0.627, P=0.021) and correlated with hemoglobin A1c, eGFR, diabetes duration, systolic blood pressure, serum creatinine, and UACR.

Conclusions:

  • Serum DKK1 levels are negatively associated with UACR in T2D patients.
  • Lower serum DKK1 levels may indicate an increased risk of albuminuria and DKD progression.
Keywords:
AlbuminuriaDiabetic kidney diseaseDickkopf-1MicroalbuminuriaType 2 diabetic mellitusWingless

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