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Updated: Nov 19, 2025

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
Published on: October 22, 2014
Positive and negative well-being of older adults with symptomatic peripheral artery disease: A population-based
Snorri Bjorn Rafnsson1, Gerry Fowkes2
1Geller Institute of Ageing and Memory, School of Biomedical Sciences, University of West London, London, UK.
Objective:
We investigated positive and negative subjective well-being in relation to lower-extremity peripheral artery disease (PAD) in a sample of older adults.
Method:
4760 participants in the English Longitudinal Study of Ageing (ELSA) provided baseline data on symptomatic PAD, sociodemographic characteristics, lifestyle risk factors, and co-morbid conditions. Baseline and two-year follow-up data were available for life satisfaction, quality of life, and depressive symptoms.
Results:
Participants with PAD symptoms had lower baseline levels of life satisfaction (β = -0.03, p < .05) and quality of life (β = -0.04, p < .01), and more depressive symptoms (β = 0.03, p < .05). These associations remained statistically significant in multivariate analyses. Baseline PAD did not, however, influence well-being levels at two-year follow-up.
Discussion:
Greater awareness of the potential for chronic vascular morbidity to disrupt the lives of older adults is needed to inform effective multidisciplinary support and interventions that help maintain the quality of life of those affected.
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