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Updated: Nov 19, 2025
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Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
Published on: July 5, 2019
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Concomitant Pathogenic Mutations and Fusions of Driver Oncogenes in Tumors
Runjiao Zhang1,2, Li Dong1, Jinpu Yu1,2
1Cancer Molecular Diagnostics Core, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, China.
Frontiers in Oncology
|February 1, 2021
Summary
Driver oncogene alterations are key to tumor development. This review examines how co-occurring mutations and fusions in driver oncogenes impact lung cancer, thyroid cancer, and leukemia.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Driver oncogene alterations are fundamental to tumor initiation and progression.
- Previous research has extensively detailed the roles of specific driver oncogenes in various cancers.
- The interplay between driver oncogene mutations and gene fusions is an emerging area of significant interest.
Purpose of the Study:
- To review the phenomenon of concomitant driver oncogene mutations and fusions.
- To analyze the coexistence and mutual exclusivity of these alterations.
- To focus on three common carcinoma types: lung cancer, thyroid cancer, and leukemia.
Main Methods:
- Literature review of studies investigating driver oncogene alterations.
- Analysis of reported cases of concomitant mutations and fusions.
- Comparative analysis across lung cancer, thyroid cancer, and leukemia.
Main Results:
- Driver oncogene alterations significantly influence tumorigenesis and cancer progression.
- Concomitant mutations and fusions in driver oncogenes are frequently observed, exhibiting patterns of coexistence and mutual exclusivity.
- These phenomena are particularly well-documented in lung cancer, thyroid cancer, and leukemia.
Conclusions:
- Understanding concomitant driver oncogene alterations is crucial for comprehending cancer development.
- The interplay between mutations and fusions provides insights into cancer heterogeneity and therapeutic strategies.
- Further research into these combined alterations in various carcinomas is warranted.
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