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Lobular Breast Cancer: A Review
Natalie Wilson1, Alastair Ironside2, Anna Diana3
1Cancer Research UK, Edinburgh Centre, MRC Institute Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Frontiers in Oncology
|February 1, 2021
Summary
Invasive lobular carcinoma (ILC), a subtype of breast cancer, presents unique diagnostic and treatment challenges due to its distinct biology. Understanding ILC
Area of Science:
- Oncology
- Pathology
- Genetics
Background:
- Invasive lobular carcinoma (ILC) incidence is rising, accounting for 5%-15% of invasive breast cancers.
- ILC is characterized by E-cadherin loss, discohesive morphology, single-file proliferation, and estrogen receptor positivity.
- These features complicate physical and imaging detection.
Purpose of the Study:
- To review the unique biological and molecular features of ILC.
- To highlight diagnostic challenges associated with ILC.
- To discuss current and prospective management strategies for ILC.
Main Methods:
- Literature review focusing on ILC biology, diagnosis, and treatment.
- Synthesis of information on molecular hallmarks and clinical presentation.
- Exploration of therapeutic options based on ILC's distinct characteristics.
Main Results:
- ILC's biological features, such as E-cadherin loss, pose diagnostic difficulties.
- Endocrine therapy is preferred due to ILC's low chemosensitivity and response rates.
- Current management involves specific surgical and medical strategies tailored to ILC.
Conclusions:
- A deeper understanding of ILC's biology is crucial for improving patient treatment.
- Future therapeutic strategies must address the unique molecular profile of ILC.
- Continued research is essential for optimizing ILC management and outcomes.
