The ACTTION Guide to Clinical Trials of Pain Treatments, part II: mitigating bias, maximizing value
Related Experiment Video
Updated: Nov 19, 2025

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
Published on: April 14, 2016
Robert H Dworkin1, Robert D Kerns2, Michael P McDermott3
1Departments of Anesthesiology and Perioperative Medicine, Neurology, and Psychiatry, Center for Health + Technology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Abstract:
Summaries of the articles included in part II of the ACTTION Guide to Clinical Trials of Pain Treatments are followed by brief overviews of methodologic considerations involving precision pain medicine, pragmatic clinical trials, real world evidence, and patient engagement in clinical trials.
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