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Updated: Nov 19, 2025

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Published on: June 21, 2022
Heat inactivation of the severe acute respiratory syndrome coronavirus 2
Christophe Batéjat1, Quentin Grassin1, Jean-Claude Manuguerra1
1Institut Pasteur, Unité Environnement et Risques Infectieux, Cellule d'Intervention Biologique d'Urgence (CIBU), 28 rue du Dr. Roux, Paris, France.
Abstract:
Cell culture medium, nasopharyngeal and sera samples spiked with SARS-CoV-2 were subjected to heat inactivation for various periods of time, ranging from 30 s to 60 min. Our results showed that SARS-CoV-2 could be inactivated in less than 30 min, 15 min, and 3 min at 56 °C, 65 °C, and 95 °C, respectively. These data could help laboratory workers to improve their protocols by handling the virus in biosafety conditions.
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