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A Multifunctional Origami Patch for Minimally Invasive Tissue Sealing.

Sarah J Wu1, Hyunwoo Yuk1, Jingjing Wu1

  • 1Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

Advanced Materials (Deerfield Beach, Fla.)
|February 1, 2021
PubMed
Summary

A novel multilayer bioadhesive patch offers advanced tissue sealing for minimally invasive surgery. This fluid-repellent, pressure-triggered sealant resists biofouling and inflammation, overcoming limitations of current surgical sealants.

Keywords:
antifouling materialsbioadhesivesminimally invasive surgeryorigami-based manufacturingwound sealing

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Area of Science:

  • Biomaterials Science
  • Surgical Innovation
  • Minimally Invasive Surgery

Background:

  • Bioadhesive materials show promise for replacing sutures and staples in minimally invasive surgery.
  • Existing bioadhesives face challenges in fluid-rich environments and delivery through narrow surgical spaces.
  • Limitations hinder the translation of current sealants for widespread surgical use.

Purpose of the Study:

  • To introduce a novel multilayer bioadhesive patch for effective minimally invasive tissue sealing.
  • To design a patch capable of repelling body fluids and adhering to wet tissues under pressure.
  • To develop a sealant resistant to biofouling and inflammation for enhanced surgical outcomes.

Main Methods:

  • Fabrication of a multilayer bioadhesive patch combining microtextured bioadhesive, hydrophobic fluid, and zwitterionic nonadhesive layers.
  • Integration of the patch with minimally invasive surgical tools using origami-based strategies.
  • Evaluation of adhesion strength, fluid repellency, and resistance to bacterial adhesion and inflammation in ex vivo models.

Main Results:

  • The multilayer patch demonstrated robust adhesion to wet tissues, even in the presence of blood.
  • The patch effectively repelled body fluids and resisted biofouling, including bacterial adhesion and protein adsorption.
  • Origami-based integration facilitated facile tissue sealing in ex vivo porcine models.

Conclusions:

  • The developed bioadhesive patch presents a significant advancement for minimally invasive tissue sealing.
  • Its unique design overcomes key limitations of current surgical sealants, offering enhanced performance in physiological conditions.
  • This technology holds potential for diverse clinical applications in minimally invasive surgery.