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An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation

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Low-Power Near-Infrared-Responsive Upconversion Nanovectors.

Jun Xiang¹, Shenglin Zhou¹, Jianxun Lin¹

¹College of Biomass Science and Engineering, Key Laboratory of Leather Chemistry and Engineering of Ministry of Education, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, P.R. China.

ACS Applied Materials & Interfaces

|February 1, 2021

Summary

Researchers developed new upconversion nanoparticle-based photoresponsive nanovectors (UCPNVs) using a facile synthesis. These UCPNVs efficiently release an anticancer drug under low-power near-infrared (NIR) light, minimizing tissue damage.

Keywords:

Passerini three-component reaction low-power NIR excitation monodisperse perylene-derived photocage upconversion nanoparticle-based photoresponsive nanovectors

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Area of Science:

Nanotechnology
Materials Science
Photochemistry

Background:

Upconversion nanoparticle-based photoresponsive nanovectors (UCPNVs) offer deep tissue stimulation with reduced photodamage via low-power near-infrared (NIR) excitation.
Developing efficient and convenient synthesis methods for UCPNVs is crucial for their biomedical applications.

Purpose of the Study:

To develop a facile and effective strategy for constructing surface-decorated UCPNVs.
To create UCPNVs with a tailored deprotecting wavelength matching upconversion blue light.
To demonstrate the controlled release of an anticancer drug using these novel UCPNVs.

Main Methods:

Utilized Passerini three-component reaction (P-3CR) for UCPNV synthesis.
Incorporated 3-perylenecarboxaldehyde, Tm3+/Yb3+ ion-doped upconversion nanoparticle (UCNP)-containing isocyanides, and chlorambucil.
Investigated the release of caged chlorambucil under low-power 976 nm NIR excitation.

Main Results:

Successfully synthesized monodisperse UCPNVs with a tailored deprotecting wavelength.
Achieved efficient release of the caged anticancer agent chlorambucil.
Demonstrated effective drug release at very low 976 nm excitation power.

Conclusions:

The P-3CR strategy provides a convenient and effective route for developing UCPNVs.
These UCPNVs are promising for UCNP-assisted low-power NIR photochemistry and targeted drug delivery.
The developed materials expand synthetic options for advanced nanomedicine applications.