Related Experiment Video
Updated: Nov 19, 2025

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze
Published on: July 29, 2025
Sex/gender differences in the neural substrate of long-term memory
1Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.
None:
Sex/gender-related differences in neurocognitive task performance and their neural correlates have long been of substantial research interest. Spets & Slotnick's robust study joins a growing body of evidence that significant sex/gender differences exist in long term memory and neurocognition more broadly. In addition to fundamental differences in the neural substrate, hormonal cycles, divergent neurodevelopmental trajectories, sex versus gender identification and sociocultural and educational influences are likely important factors. Building upon these findings, future studies in larger sample sizes should carefully measure these potential modulating and/or confounding variables in order to provide a nuanced picture of sex/gender-related differences in brain function.
Related Concept Videos
Long-Term Memory
Long-term memory can be categorized into two primary types: explicit and implicit memory. Explicit memory, also known as declarative memory, involves the conscious recollection of information that we deliberately try to remember, recall, and articulate. This type of memory encompasses specific facts, events, and...
Role of Neurotransmitters in Memory
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
System of Memory
Long-term Depression
Calcium Ion Concentration Mechanism
If over...
Long-term Depression
Role of Cerebellum and Prefrontal Cortex in Memory

