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Updated: Nov 19, 2025

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
[Detection of peripheral artery disease in patients with ischemic heart disease. A quick guide for medical
1Scientific and Clinical Center of The Federal Mediacal and Biological Agency of Russia, Moscow.
Insights
This manual details diagnosing peripheral artery disease in heart patients, emphasizing methods to reduce cardiovascular events (CVE) and mortality. Intensifying antithrombotic therapy, as shown by the COMPASS study, can lower CVE risk.
Area of Science:
- Cardiology
- Vascular Medicine
- Diagnostic Imaging
Background:
- Peripheral artery disease (PAD) is a significant risk factor for cardiovascular events (CVE) in cardiological patients.
- Accurate diagnosis and risk stratification are crucial for effective management and prevention of adverse outcomes.
- Current diagnostic approaches require comprehensive evaluation from initial patient contact to advanced imaging.
Purpose of the Study:
- To outline principal diagnostic methods for peripheral artery disease (PAD) in cardiology patients.
- To discuss the diagnostic and prognostic value of various assessment techniques.
- To explore the potential of these methods in reducing the risk of cardiovascular events (CVE) and overall mortality.
Main Methods:
- Review of diagnostic strategies, including patient interview and physical examination.
- Evaluation of functional tests for assessing peripheral circulation.
- Discussion of vascular visualization techniques for anatomical and functional assessment.
Main Results:
- Each diagnostic method's value in identifying PAD and predicting patient outcomes is analyzed.
- The potential of diagnostic findings to guide interventions for reducing myocardial infarction (MI), ischemic stroke (IS), and amputation is highlighted.
- Current evidence, including the COMPASS study, suggests intensified antithrombotic therapy can reduce CVE risk in PAD patients.
Conclusions:
- Comprehensive diagnostic evaluation is essential for managing PAD in cardiological patients.
- Early and accurate diagnosis facilitates risk stratification and targeted therapeutic strategies.
- Optimizing antithrombotic therapy based on diagnostic results is a key approach to mitigate cardiovascular risk.
Abstract:
In this manual, the authors focused on the principal methods for diagnosis of peripheral artery disease in cardiological patients, from the interview and physical examination to functional tests and vascular visualization. Diagnostic and prognostic value of each method, its potentialities for reducing the risk of cardiovascular events (CVE), including myocardial infarction (MI), ischemic stroke (IS) or extremity amputation in critical ischemia, and overall mortality are discussed. The authors provided current information about a possibility of reducing the risk of CVE by intensifying the antithrombotic therapy according to results of the COMPASS study.
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