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Lymphovenous shunts: from development to clinical applications.
A Blake Tucker1, Pranav Krishnan1, Shailesh Agarwal2
1University of Chicago Pritzker School of Medicine, Chicago, IL, USA.
Microcirculation (New York, N.Y. : 1994)
|February 1, 2021
Summary
Lymphovenous shunts connect lymphatic and venous systems naturally or surgically. Understanding these shunts is key to treating conditions like lymphedema and other diseases.
Area of Science:
- Vascular Biology
- Surgical Anatomy
Background:
- The lymphatic system returns excess interstitial fluid to the bloodstream.
- Lymphovenous shunts are connections between lymphatic and venous systems, occurring naturally or surgically.
- These shunts are found centrally (e.g., thoracic duct) and peripherally (e.g., lymph nodes).
Purpose of the Study:
- To discuss anatomic and surgical lymphovenous shunts.
- To provide an understanding of their role in health and disease.
- To illustrate their surgical application in treating diseases.
Main Methods:
- Review of anatomic lymphovenous shunts.
- Discussion of pathological lymphovenous shunts in disease states.
- Exploration of surgical lymphovenous shunt construction for therapeutic purposes.
Main Results:
- Anatomic lymphovenous shunts include major duct connections and peripheral anastomoses.
- Pathologic lymphovenous shunts are implicated in lymphedema, malignancy, and malformations.
- Surgical lymphovenous shunts can be created to manage lymphedema.
Conclusions:
- Lymphovenous shunts play a critical role in fluid balance and disease pathology.
- Understanding lymphovenous shunts is essential for both basic science and clinical applications.
- Surgical creation of lymphovenous shunts offers a therapeutic strategy for specific medical conditions.
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