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Related Experiment Videos

Sensorineural hearing loss in sickle cell crisis.

S Elwany1, T Kamel

  • 1Department of Otolaryngology, Dr. Fakhry Hospital, Alkhobar, Saudi Arabia.

The Laryngoscope
|April 1, 1988
PubMed
Summary

Sickle cell crisis can impact hearing and auditory brainstem responses (ABR). While some hearing loss and ABR abnormalities were observed, many improved after the crisis subsided.

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Area of Science:

  • Audiology
  • Hematology
  • Neurology

Background:

  • Sickle cell disease (SCD) is a genetic blood disorder.
  • SCD complications can affect various organ systems.
  • Auditory function in SCD patients requires further investigation.

Purpose of the Study:

  • To evaluate peripheral auditory function in sickle cell crisis.
  • To assess auditory brainstem response (ABR) changes during and after sickle cell crisis.
  • To explore the relationship between sickle cell crisis severity and auditory system alterations.

Main Methods:

  • Study included 10 patients with homozygous sickle cell anemia (SS hemoglobin).
  • Auditory function and ABR testing were conducted during crisis and 1 month post-crisis.
  • Analysis focused on high-frequency hearing loss and ABR waveform abnormalities.

Main Results:

  • Three patients exhibited unilateral high-frequency hearing loss during crisis; one showed persistent loss.
  • Four patients had abnormal ABR tracings, with one normalizing post-crisis.
  • A trend suggested increased sensorineural hearing loss (SNHL) and ABR changes with higher crisis frequency and severity.

Conclusions:

  • Sickle cell crisis may transiently affect peripheral auditory function and ABR.
  • Sensorineural hearing loss and ABR abnormalities appear linked to crisis burden.
  • Further research is warranted to understand the long-term auditory implications of SCD.

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