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Sialadenoma Papilliferum.

Min-Shu Hsieh1, Justin A Bishop2, Julia Yu Fong Chang3

  • 1Department of Pathology, National Taiwan University Hospital, No 7, Chung-Shan South Road, Taipei 100, Taiwan; Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei, Taiwan.

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|February 2, 2021
PubMed
Summary

Sialadenoma papilliferum (SP) is a rare salivary gland tumor. Diagnosis can be challenging, but SOX10 immunohistochemistry and BRAF analysis aid in differentiating it from similar conditions.

Keywords:
BRAF V600E mutationClassicHRAS Q61R mutationOncocyticSialadenoma papilliferum

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Area of Science:

  • Oral pathology
  • Surgical oncology
  • Genetics

Background:

  • Sialadenoma papilliferum (SP) is a rare benign salivary gland neoplasm.
  • It shares histopathologic features and genetic alterations (BRAF V600E or HRAS mutations) with syringocystadenoma papilliferum.
  • SP typically affects older adults and commonly occurs on the hard palate.

Purpose of the Study:

  • To describe the clinicopathologic features of Sialadenoma papilliferum.
  • To highlight diagnostic challenges and differential considerations.
  • To evaluate the efficacy of treatment and recurrence rates.

Main Methods:

  • Review of histopathologic features of SP.
  • Analysis of clinical presentation and patient demographics.
  • Discussion of genetic alterations (BRAF V600E, HRAS mutations) and immunohistochemical markers (SOX10).

Main Results:

  • SP presents with exophytic papillary epithelial and endophytic ductal proliferation.
  • Two subtypes exist: classic and oncocytic.
  • Clinical diagnosis often mimics squamous papilloma.
  • Conservative surgical treatment is generally effective with low recurrence rates.

Conclusions:

  • Sialadenoma papilliferum is a distinct benign salivary gland neoplasm.
  • Accurate diagnosis requires careful histopathologic evaluation, potentially aided by SOX10 immunohistochemistry and BRAF analysis.
  • Conservative surgical management is recommended.