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Child health after preimplantation genetic testing

Sharon Lewis1, David J Amor1, Anne Glynn2

  • 1Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne Victoria, Australia; Department of Paediatrics, University of Melbourne, Melbourne Victoria, Australia.

Reproductive Biomedicine Online
|February 2, 2021
PubMed

Insights

Preimplantation genetic testing (PGT) does not appear to cause adverse health or developmental outcomes in school-aged children. This study found no significant differences in health and well-being between children conceived with PGT and those conceived via IVF alone.

Area of Science:

  • Reproductive Medicine
  • Human Genetics
  • Pediatric Health

Background:

  • Preimplantation genetic testing (PGT) is increasingly used for aneuploidy and monogenic diseases.
  • Limited long-term follow-up data exists for children conceived via PGT beyond age two.
  • This study addresses the health and developmental outcomes of school-aged children conceived after PGT.

Purpose of the Study:

  • To examine the health, well-being, and development of school-aged children (5-8 years) conceived following PGT.
  • To compare outcomes in children conceived with PGT to those conceived with IVF alone.
  • To assess potential long-term effects of PGT on child development and family functioning.

Main Methods:

  • Retrospective cohort study comparing children conceived after IVF with PGT (exposed) and IVF without PGT (unexposed).
  • Two IVF clinics in Melbourne, with children born between 2000-2008.
  • Maternal questionnaires assessed child health, well-being, development, education, and family functioning.

Main Results:

  • 155 participants in the PGT cohort and 303 in the IVF-only cohort.
  • No significant differences in maternal/pregnancy characteristics, except higher C-section rates in PGT singletons.
  • No significant differences in most health/psychological scales; PGT cohort showed more positive outcomes in some measures.

Conclusions:

  • PGT does not appear to be associated with adverse outcomes in school-aged children.
  • Findings suggest PGT is safe for child development and well-being.
  • Limitations include self-reported data and a relatively small sample size.
Abstract

Keywords:
Developmental healthIVFPreimplantation genetic testingWell-being

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