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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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Evolving Status of Clinical Immunotherapy with Oncolytic Adenovirus

Martí Farrera-Sal1,2, Laura Moya-Borrego1, Miriam Bazan-Peregrino2

  • 1ProCure Program, IDIBELL-Institut Català d'Oncologia, Barcelona, Spain.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|February 2, 2021
PubMed

Insights

Oncolytic adenoviruses show promise for treating "cold tumors" unresponsive to immunotherapy by triggering immune responses. This review covers preclinical and clinical data, focusing on combination strategies for enhanced cancer treatment.

Area of Science:

  • Oncology
  • Immunology
  • Virology

Background:

  • Cancer immunotherapy using immune checkpoint inhibitors is effective but limited in
  • cold tumors
  • lacking immune cells.
  • Oncolytic viruses are being explored to enhance anti-tumor immunity.

Purpose of the Study:

  • To review the use of oncolytic adenoviruses in cancer immunotherapy.
  • To focus on preclinical and clinical data of oncolytic adenovirus-triggered immune responses against tumor antigens.
  • To discuss clinical trial design and combination strategies.

Main Methods:

  • Review of preclinical and clinical data on oncolytic adenoviruses.
  • Analysis of oncolytic adenovirus-mediated immune responses against tumor antigens.
  • Discussion of clinical trial parameters and combination therapies.

Main Results:

  • Oncolytic adenoviruses demonstrate potential in triggering immune responses against tumors.
  • Preclinical and clinical data support the immunogenic mechanisms of oncolytic adenoviruses.
  • Combination strategies may enhance therapeutic efficacy.

Conclusions:

  • Oncolytic adenoviruses represent a promising approach to overcome unresponsiveness in
  • cold tumors
  • by stimulating anti-tumor immunity.
  • Further research and optimized clinical trial designs are crucial for their successful integration into cancer treatment regimens.

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