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Changing mindsets about side effects.

Kari A Leibowitz1, Lauren C Howe2, Alia J Crum1

  • 1Department of Psychology, Stanford University, Stanford, California, USA kleibow@stanford.edu lauren.howe@business.uzh.ch crum@stanford.edu.

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|February 2, 2021
PubMed
Summary
This summary is machine-generated.

Communicating treatment side effects can worsen them. Framing minor side effects as signs of treatment efficacy can improve patient experience and outcomes, reducing anxiety and increasing treatment effectiveness.

Keywords:
adverse eventsepidemiologygeneral medicine (see internal medicine)primary carequality in health care

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Area of Science:

  • Medical communication
  • Patient psychology
  • Treatment adherence

Background:

  • Communicating treatment side effects can paradoxically increase their occurrence.
  • Healthcare providers face a challenge in informing patients about side effects without causing unnecessary harm.

Purpose of the Study:

  • To explore an emerging communication strategy where minor side effects are presented as indicators of treatment effectiveness.
  • To evaluate the impact of this approach on patient anxiety, perception of side effects, and treatment outcomes.

Main Methods:

  • Review of existing research on communication strategies for treatment side effects.
  • Analysis of a longitudinal, randomized controlled trial involving oral immunotherapy for food allergies.

Main Results:

  • Patients informed that side effects signal treatment efficacy reported less anxiety and perceived side effects as less threatening and intense compared to standard communication.
  • The intervention group showed a reduced rate of contacting providers about side effects.
  • A significant increase in peanut-specific blood IgG4, a biomarker of allergic tolerance, was observed in the intervention group.

Conclusions:

  • Framing minor side effects as signs of treatment working is a promising strategy to improve patient experience and treatment outcomes.
  • This approach may reduce patient anxiety and enhance treatment effectiveness, particularly in conditions like allergies.
  • Further research is needed to determine the optimal application of this strategy across different treatments and symptoms.