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Lower risk of subarachnoid haemorrhage in diabetes: a nationwide population-based cohort study

Jang Hoon Kim1, Jimin Jeon2, Jinkwon Kim3

  • 1Department of Neurosurgery, Yongin Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

Stroke and Vascular Neurology
|February 2, 2021
PubMed

Insights

Diabetes mellitus (DM) is linked to a lower risk of subarachnoid hemorrhage (SAH). Elevated fasting blood glucose also showed a protective association against SAH, warranting further investigation into hyperglycemia

Area of Science:

  • Neurology
  • Endocrinology
  • Public Health

Background:

  • Diabetes mellitus (DM) is a common metabolic disorder.
  • DM is associated with increased cardiovascular and cerebrovascular risks.
  • The link between DM and subarachnoid hemorrhage (SAH) risk is debated.

Purpose of the Study:

  • To investigate the association between DM and the risk of SAH.
  • To analyze the relationship using a large-scale, population-based health screening database.

Main Methods:

  • Retrospective cohort study design.
  • Included over 421,000 participants from a Korean nationwide health screening program (2003-2004).
  • Utilized Cox proportional hazards regression, adjusting for multiple confounding factors.

Main Results:

  • Diabetes mellitus (DM) was associated with a significantly decreased risk of SAH (adjusted HR 0.68).
  • Elevated fasting blood glucose levels were also inversely associated with SAH risk (adjusted HR per 1 mmol/L increase 0.90).
  • The study followed 1039 SAH cases over a mean of 11.6 years.

Conclusions:

  • Diabetes mellitus and elevated fasting blood glucose show an inverse association with subarachnoid hemorrhage risk.
  • These findings suggest a potentially protective role of hyperglycemia in SAH.
  • Further research is needed to understand the pathophysiological mechanisms involved.
Abstract

Keywords:
aneurysmstrokesubarachnoid

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