Related Experiment Video

Updated: Nov 19, 2025

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
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Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

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The role of MET in chemotherapy resistance

Georgina E Wood1, Helen Hockings2, Danielle M Hilton2

  • 1Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK. georgina.wood3@nhs.net.

Oncogene
|February 2, 2021
PubMed

Insights

Chemotherapy resistance is a major challenge in cancer treatment. The receptor tyrosine kinase MET may promote resistance to chemotherapy, suggesting MET inhibitors could be a potential therapeutic strategy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Cytotoxic chemotherapy is a primary cancer treatment, but resistance is a significant clinical hurdle.
  • The receptor tyrosine kinase MET is implicated in various cancers and associated with poor prognosis.
  • MET is known to drive resistance to targeted therapies like EGFR, BRAF, and MEK inhibitors.

Purpose of the Study:

  • To review preclinical evidence on the role of MET in chemotherapy resistance.
  • To elucidate the mechanisms by which MET mediates chemotherapy resistance.
  • To discuss the translational relevance of MET inhibitors for patients with resistant cancers.

Main Methods:

  • Review of preclinical studies investigating MET and chemotherapy resistance.
  • Analysis of molecular mechanisms underlying MET-mediated resistance.
  • Evaluation of clinical trial data for MET inhibitors in resistant malignancies.

Main Results:

  • Preclinical data indicate that MET overexpression contributes to resistance against cytotoxic chemotherapy.
  • MET signaling pathways are involved in mediating this chemoresistance.
  • MET inhibitors show potential in overcoming chemotherapy resistance in preclinical models.

Conclusions:

  • MET plays a significant role in the development of chemotherapy resistance across various cancers.
  • Targeting MET with inhibitors presents a promising therapeutic avenue for overcoming treatment resistance.
  • Further clinical investigation of MET inhibitors is warranted for patients with chemotherapy-resistant malignancies.

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