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Updated: Nov 19, 2025

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
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Src-family Protein Tyrosine Kinases: A promising target for treating Cardiovascular Diseases

Yuhong Zhai1,2,3, Jun Yang1,2, Jing Zhang2,3

  • 1Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang 443000, China.

International Journal of Medical Sciences
|February 2, 2021
PubMed

Insights

Src-family kinases (SFKs) are crucial for heart function and homeostasis. Their altered activity influences cardiovascular diseases, making them potential biomarkers and therapeutic targets.

Area of Science:

  • Cardiovascular Biology
  • Molecular Cardiology
  • Biochemistry

Background:

  • Src-family kinases (SFKs) are non-receptor tyrosine kinases ubiquitously expressed in various cell types.
  • SFKs play a critical role in signal transduction pathways governing cardiac physiological and pathological processes.
  • SFK activity is intrinsically linked to maintaining cardiovascular homeostasis.

Purpose of the Study:

  • To review the fundamental information regarding SFKs.
  • To update the understanding of SFKs' roles in the development of cardiovascular diseases (CVDs).
  • To highlight the potential of SFKs as biomarkers and therapeutic targets for CVDs.

Main Methods:

  • Literature review of studies on SFKs in cardiovascular physiology and pathology.
  • Analysis of SFK involvement in cellular processes like growth, differentiation, movement, and function.
  • Examination of SFK regulation of electrophysiologic signals in the heart.

Main Results:

  • SFK phosphorylation states are altered by various injury factors and stress.
  • SFKs modulate diverse cardiac pathological conditions, including hypertension, coronary heart disease, and cardiomyopathy.
  • SFKs regulate critical cellular functions and electrophysiologic signals in the heart.

Conclusions:

  • SFKs are integral to cardiac function and homeostasis.
  • Dysregulated SFK activity contributes significantly to the pathophysiology of multiple cardiovascular diseases.
  • SFKs represent promising targets for novel diagnostic and therapeutic strategies in cardiology.
Keywords:
Src-family protein tyrosine kinasescoronary heart diseasehypertensionischemic heart diseasemyocardial ischemia reperfusion injury

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