Hydrogenative-PHIP polarized metabolites for biological studies

Area of Science:

• Magnetic Resonance Imaging
• Hyperpolarization Techniques
• Biomedical Applications

Background:

• ParaHydrogen induced polarization (PHIP) is a cost-effective hyperpolarization method.
• Chemical challenges have limited PHIP's application in biological investigations.
• Traditional PHIP requires a de-hydrogenated precursor, limiting substrate availability.

Purpose of the Study:

• To review advancements in hydrogenative PHIP (h-PHIP) for biological applications.
• To focus on substrates hyperpolarized using h-PHIP and utilized in vivo.
• To discuss requirements and challenges for future PHIP substrate development.

Main Methods:

• Review of recent advancements in hydrogenative PHIP (h-PHIP).
• Focus on substrates developed via h-PHIP for in vivo studies.
• Analysis of requirements and challenges for in vivo PHIP applications.

Main Results:

• Hydrogenative PHIP (h-PHIP) has significantly expanded the range of hyperpolarizable metabolites.
• Several PHIP substrates have been successfully used in vivo.
• The review highlights the progress and potential of h-PHIP in biological investigations.

Conclusions:

• Advancements in h-PHIP have overcome previous limitations, enabling broader in vivo applications.
• Further research is needed to address remaining challenges and optimize PHIP substrates for biological use.
• PHIP holds significant promise for enhancing biological imaging and diagnostics.