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Published on: January 28, 2019
Epidemiology and Genotype Distribution of Rotavirus Gastroenteritis in Under-Five Children of South Rajasthan, India
Bhupesh Jain1, Suresh Goyal2, Lakhan Poswal2
1Department of Pediatrics, RNT Medical College, Udaipur, Rajasthan, 313001, India. drbhupeshudr@gmail.com.
Insights
Rotavirus diarrhea affected 12.9% of hospitalized children under five in Udaipur. The most common strain was G3P[8], highlighting the need for targeted prevention strategies for rotavirus gastroenteritis.
Area of Science:
- Pediatrics
- Infectious Diseases
- Epidemiology
Background:
- Rotavirus gastroenteritis is a major cause of severe diarrhea in children globally.
- Understanding local epidemiology and circulating strains is crucial for effective control measures.
Purpose of the Study:
- To investigate the prevalence and genotypes of rotavirus among children under five hospitalized with acute gastroenteritis in Udaipur, Rajasthan.
- To determine the epidemiological characteristics and clinical presentation of rotavirus infections in this population.
Main Methods:
- A prospective hospital-based study was conducted from 2017-2019.
- Enzyme immune assay (EIA) was used to detect rotavirus in stool samples from 734 children (0-59 months).
- Positive samples underwent genotyping using established methods.
Main Results:
- Rotavirus was detected in 12.94% of cases.
- Peak incidence occurred in children aged 6-23 months.
- Higher detection rates were observed during winter months (December-February).
- G3P[8] was the predominant genotype (43.01%), followed by G9P[4] (10.75%).
- Severe dehydration was present in 65% of rotavirus-infected children.
Conclusions:
- Rotavirus is a significant cause of severe gastroenteritis in hospitalized children under five in Udaipur.
- The G3P[8] genotype is the most prevalent circulating strain in this region.
- Findings emphasize the importance of rotavirus surveillance and vaccination programs.
Objective:
To determine the epidemiology of rotavirus diarrhea and its genotypes distribution among under five children from Udaipur, Rajasthan.
Methods:
Hospital-based prospective study among children aged 0-59 mo of age hospitalized due to acute gastroenteritis and assess the clinical and epidemiological profile. Stool samples collected during 2017-2019 from 734 children, were tested by enzyme immune assay (EIA) to identify rotavirus and the samples that were positive were subjected to genotyping using published methods.
Results:
Rotavirus was detected in 12.94% (95/734) of the stool samples. Maximum positivity (38.9%) was seen in children aged 12-23 mo followed by 34.7% in 6-11 mo of age. Detection rates were higher (46.31%, 44/95) during winter months of December-February; 65% children with rotavirus diarrhea had severe dehydration followed by moderate dehydration in 32% of cases. G3P[8] (40, 43.01%) was the commonest genotype followed by G9P[4] (10, 10.75%).
Conclusion:
Among under-five children hospitalized due to acute gastroenteritis in a tertiary care setting in Udaipur, Rajasthan, 12.9% of children were rotavirus positive with predominant (43.01%) circulation of G3P[8] strains.
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