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Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

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In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
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Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
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Updated: Nov 19, 2025

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies
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Liver Function Status in COVID-19: An Indian Perspective.

Kheya Mukherjee1, Abhra Banerjee2, Debojyoti Bhattacharjee3

  • 1Associate Professor, ID & BG Hospital, Kolkata, West Bengal.

The Journal of the Association of Physicians of India
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Summary
This summary is machine-generated.

COVID-19 patients commonly show liver function test derangements, particularly in severe cases. Further research is needed to understand the long-term effects of this liver injury.

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Area of Science:

  • Hepatology
  • Infectious Diseases
  • Virology

Background:

  • SARS-CoV2 infection can affect multiple organs, including the liver.
  • While mild liver function derangements are common in COVID-19 patients, significant liver injury is considered infrequent.
  • This study investigated the clinical characteristics of COVID-19 patients and their relationship with liver parameters.

Purpose of the Study:

  • To describe the clinical characteristics of COVID-19 patients admitted to a level 4 COVID hospital.
  • To investigate the relationship between clinical characteristics and liver function parameters in COVID-19 patients.
  • To assess liver enzyme and albumin levels across different severity groups of COVID-19.

Main Methods:

  • COVID-19 patients were classified into mild, moderate, and severe groups.
  • Serum samples were analyzed for total and direct bilirubin, Alanine Transaminase (ALT), Aspartate Transaminase (AST), Alkaline Phosphatase (ALKP), total protein, and albumin.
  • Biochemistry autoanalyzer was used for serum sample analysis.

Main Results:

  • Higher Body mass index (BMI) correlated with increased COVID-19 complications and need for higher care (HDU/ICU).
  • Alanine Transaminase (ALT) and Aspartate Transaminase (AST) levels were elevated in all patients, with no significant inter-group differences.
  • Serum albumin levels were significantly reduced in moderate and severe COVID-19 groups compared to the mild group.

Conclusions:

  • Liver function test (LFT) derangements are frequent in COVID-19 patients, especially those with severe disease.
  • The long-term impact of COVID-19-related liver injury remains unknown.
  • Further investigation and long-term follow-up are necessary to understand the pathophysiology and implications of liver injury in COVID-19 recovery.