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8-Aminoimidazo[1,2-a]pyridine (AIP) directed Pd(II) catalysis: site-selective ortho-C(sp2)-H arylation in aqueous
Biswajit Mondal1, Prasanjit Ghosh2, MrinalKanti Kundu3
1TCG Life sciences Pvt. Ltd, BN-7, Sector V, Salt Lake City, Kolkata 700091, India. mrinal.kundu@tcgls.com and Department of Chemistry, University of North Bengal, Darjeeling 734013, India. sajaldas@nbu.ac.in.
Abstract:
We demonstrate herein the first example of a palladium(ii) catalyzed regioselective ortho-C(sp2)-H arylation in aqueous medium (a sustainable solvent) utilizing 8-AIP (8-aminoimidazo[1,2-a]pyridine) as a promising and removable bidentate directing group/auxilliary. This newly developed protocol features a broad substrate scope with excellent functional group tolerance and enables an expeditious route to a library of unsymmetrical amides in good to excellent yields with exclusive site-selectivity.
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