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Bio-adhesive Nanoporous Module: Toward Autonomous Gating.

Hyuna Jo¹, Takashi Kitao², Ayumi Kimura³

¹Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

Angewandte Chemie (International Ed. in English)

|February 2, 2021

Summary

A novel bio-adhesive porous organic module, Glue COF, uses guanidinium ions for strong biopolymer adhesion. This material enables controlled release of guest molecules, demonstrated with calmodulin and Ca2+ ions.

Keywords:

adhesive materials gating phenomena host-guest chemistry porous materials

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Area of Science:

Materials Science
Supramolecular Chemistry
Nanotechnology

Background:

Covalent organic frameworks (COFs) offer tunable porous structures.
Bio-adhesion is crucial for targeted delivery and sensing applications.
Controlling guest molecule release from porous materials remains a challenge.

Purpose of the Study:

To develop a bio-adhesive porous organic module (Glue COF) with tunable release capabilities.
To investigate the mechanism of bio-adhesion via salt-bridging interactions.
To demonstrate controlled release of guest molecules using a protein-gated system.

Main Methods:

Synthesis of a guanidinium-functionalized covalent organic framework (Glue COF).
Characterization of Glue COF's porous structure and adhesive properties.
Encapsulation of sulforhodamine B (SRB) within a calmodulin-gated COF (CaM COF⊃SRB).
Investigation of SRB release triggered by Ca2+ ions.

Main Results:

Glue COF exhibits strong adhesion to biopolymers via guanidinium-oxyanionic salt bridges.
Calmodulin-gated COF successfully entrapped SRB.
Ca2+ ions triggered the release of SRB from the CaM COF⊃SRB system.
Mg2+ ions showed a significantly slower release rate, indicating selectivity.

Conclusions:

The developed Glue COF demonstrates a promising platform for bio-adhesive materials.
The protein-gated system offers a mechanism for selective and controlled guest molecule release.
This work opens avenues for advanced applications in drug delivery and sensing.