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Does a history of cardiovascular disease or cancer affect mortality after SARS-CoV-2 infection?

Rune Kvåle, Kaare Harald Bønaa, Rachel Forster

    Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
    |February 2, 2021
    PubMed

    Insights

    Age, male sex, and distant metastatic cancer were key risk factors for COVID-19 mortality in Norway. Other cardiovascular diseases and non-metastatic cancer did not significantly increase death risk after SARS-CoV-2 infection.

    Area of Science:

    • Epidemiology
    • Public Health
    • Infectious Diseases

    Background:

    • Cardiovascular disease and cancer are potential risk factors for COVID-19 mortality.
    • Previous studies suggested a link, necessitating further investigation.

    Purpose of the Study:

    • To determine if a history of cardiovascular disease or cancer impacts mortality risk following a COVID-19 diagnosis in Norway.

    Main Methods:

    • Data sourced from Norwegian national health registries.
    • Regression models (univariable and multivariable) used to assess relative and absolute risks.

    Main Results:

    • Age, male sex, prior stroke, and distant metastatic cancer independently increased COVID-19 death risk.
    • Myocardial infarction, atrial fibrillation, heart failure, hypertension, and non-metastatic cancer were not significant risk factors after adjusting for age and sex.

    Conclusions:

    • Age is the primary risk factor for COVID-19 death.
    • Male sex, stroke, and distant metastatic cancer are significant risk factors for mortality after SARS-CoV-2 infection.
    Abstract

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