Medical and Endoscopic Management of Crohn Disease

Area of Science:

• Gastroenterology and Inflammatory Bowel Diseases
• Medical Imaging in Crohn Disease
• Therapeutic Strategies for Crohn Disease

Background:

• Current Crohn disease management involves risk stratification into low-risk (mild-moderate) and high-risk (moderate-severe) categories.
• Established guidelines from international organizations guide treatment decisions for different risk profiles.

Purpose of the Study:

• To review current Crohn disease classification and risk stratification approaches.
• To detail recommended treatment strategies based on international guidelines.
• To summarize the pipeline of novel Crohn disease therapies and explore imaging's role.

Main Methods:

• Review of current literature and guidelines from key inflammatory bowel disease organizations.
• Analysis of magnetic resonance enterography and pelvis imaging findings relevant to clinical teams.
• Exploration of endoscopic and radiological targets within a treat-to-target framework.

Main Results:

• Provides a Q&A format to understand Crohn disease risk stratification.
• Details guideline-recommended treatments for mild-moderate and moderate-severe Crohn disease.
• Summarizes emerging therapies and the communication of imaging findings in multidisciplinary care.

Conclusions:

• Accurate risk stratification is crucial for tailoring Crohn disease treatment.
• Multidisciplinary collaboration, informed by imaging, optimizes patient outcomes.
• A treat-to-target approach using endoscopic and radiological markers is essential for effective Crohn disease management.