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Relationship between thiol, disulphide volume and contrast-induced nephropathy in acute coronary syndrome patients
Deniz Elcik1, Saban Kelesoglu1, Yucel Yilmaz2
1Department of Cardiology, Erciyes University Medicine Faculty, Kayseri, Turkey.
Insights
Thiol disulphide levels on admission can predict contrast-induced nephropathy (CIN) in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI). Lower thiol levels indicate a higher risk of developing CIN after PCI.
Area of Science:
- Cardiology
- Nephrology
- Biochemistry
Background:
- Contrast-induced nephropathy (CIN) is a complication following percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS).
- Identifying predictive markers for CIN is crucial for patient management and risk stratification.
Purpose of the Study:
- To evaluate the association between thiol disulphide volume and the risk of CIN in ACS patients undergoing PCI.
- To determine if thiol disulphide parameters can serve as predictive biomarkers for CIN.
Main Methods:
- 638 patients with ACS undergoing PCI were enrolled.
- Patients were categorized into groups with and without CIN based on serum creatinine levels.
- Baseline demographic, clinical, angiographic, laboratory parameters, and thiol disulphide levels were compared.
Main Results:
- Patients who developed CIN had significantly lower baseline native thiol, total thiol, and disulphide levels.
- Higher CHA2DS2-VASc scores were observed in patients with CIN.
- Native thiol and total thiol demonstrated high sensitivity and specificity in predicting CIN.
Conclusions:
- Thiol disulphide volume on admission is independently associated with CIN development post-PCI in ACS patients.
- Thiol disulphide parameters represent potential biomarkers for predicting CIN risk.
Background:
This study aimed to evaluate thiol disulphide volume for the risk of contrast-induced nephropathy (CIN) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).
Methods:
A total of 638 patients with ACS were enrolled in the study. CIN was defined as an increase in serum creatinine level of ≥0.5 mg/dL or ≥25% above baseline within 72 h after the procedure. Patients were divided into two groups: patients with and without CIN. Demographics, clinical risk factors, angiographic and laboratory parameters, CIN incidence, thiol, disulphide, and CHA2DS2-VASc score were compared between the two groups.
Results:
Native thiol, total thiol, and disulphide at baseline were significantly lower in patients who developed CIN compared to those who did not. Also, the CHA2DS2-VASc score was found to be higher in patients with CIN than those without CIN. In receiver operating characteristic analysis showed that at a cutoff of <342.1, the value of native thiol exhibited 82% sensitivity and 80% specificity for detecting CIN. Total thiol< 383.1 calculated on admission had an 80% sensitivity and 80% specificity in predicting CIN.
Conclusion:
Our study suggested that the thiol disulphide volume on admission was independently associated with the development of CIN after PCI in patients with ACS.
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