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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

15.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Mesenchymal Stem Cells01:19

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Updated: Nov 19, 2025

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch
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Cell-Inspired Biomaterials for Modulating Inflammation.

Elizabeth C Bender1, Chelsea A Kraynak1, Wenbai Huang1,2

  • 1Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, USA.

Tissue Engineering. Part B, Reviews
|February 2, 2021
PubMed
Summary
This summary is machine-generated.

Biomaterials engineered with immune-response molecules can modulate inflammation for therapeutic benefits. This review explores how these materials promote healing or combat disease by influencing immune cells and cytokines.

Keywords:
biomaterialcancercell-inspiredinflammationmacrophagenanoparticle

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Area of Science:

  • Biomaterials Science
  • Immunology
  • Biomedical Engineering

Background:

  • Inflammation is essential for healing but can worsen chronic diseases and cancer if dysregulated.
  • Current research harnesses native immune molecules within biomaterials for therapeutic applications.
  • Biomaterials offer a platform to control inflammatory responses for improved health outcomes.

Purpose of the Study:

  • To review the current landscape of engineered biomaterials that modulate inflammation.
  • To highlight strategies for using biomaterials to promote healing or combat disease.
  • To provide a resource for future research in immune engineering and biomaterials.

Main Methods:

  • Review of engineered biomaterials designed to inhibit or promote inflammation.
  • Analysis of biomaterial strategies including cytokine release/sequestration and macrophage phenotype switching.
  • Examination of biomaterial formats from nanoparticles to hydrogels and surface coatings.
  • Discussion of incorporating cell-inspired molecules into biomaterials.

Main Results:

  • Engineered biomaterials can inhibit inflammation by releasing anti-inflammatory cytokines or promoting macrophage switching.
  • Other biomaterials promote inflammation to target tumor growth by mimicking pathogen invasion.
  • Biomaterials are designed in various forms, including nanoparticles, hydrogels, and surface coatings.
  • Cell-inspired molecules are integrated into biomaterials creatively for enhanced function.

Conclusions:

  • Engineered biomaterials represent a promising approach to harness the immune system for therapeutic benefit.
  • Modulating inflammation via biomaterials can aid in treating chronic diseases and cancer.
  • Future research can build upon these findings for advanced immune engineering and biomaterial design.