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Updated: Nov 19, 2025
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Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
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Metal-catalyzed C-S bond formation using sulfur surrogates.
Nallappan Sundaravelu1, Subramani Sangeetha1, Govindasamy Sekar1
1Department of Chemistry, Indian Institute of Technology Madras, Chennai-600036, Tamil Nadu, India. gsekar@iitm.ac.in.
Organic & Biomolecular Chemistry
|February 2, 2021
Summary
This review covers advances in transition metal-catalyzed C-S bond formation using sulfur surrogates. It highlights methods for synthesizing organosulfur compounds, overcoming challenges with traditional sulfur sources.
Area of Science:
- Organosulfur chemistry and catalysis.
Background:
- Sulfur-containing compounds are vital in natural products, drugs, and materials.
- Traditional organosulfur synthesis methods face challenges like harsh conditions and catalyst poisoning.
Purpose of the Study:
- To review recent advances in transition metal-catalyzed C-S bond formation.
- To explore the use of diverse and commercially available sulfur surrogates.
- To provide insights into constructing complex organosulfur scaffolds.
Main Methods:
- Focuses on transition metal-catalyzed cross-coupling reactions and C-H bond functionalization.
- Categorizes advances by metal catalyst: palladium, copper, and others.
- Organizes findings based on various sulfur surrogates used.
Main Results:
- Demonstrates successful C-S bond formation using various metal catalysts and sulfur surrogates.
- Highlights overcoming limitations of traditional sulfur sources, such as odor and availability.
- Showcases applications in natural product synthesis and functional materials.
Conclusions:
- Transition metal catalysis offers efficient routes to organosulfur compounds.
- The use of sulfur surrogates is crucial for advancing C-S bond formation.
- This field presents growing opportunities for complex molecule synthesis and materials science.
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