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Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

846
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
846

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Related Experiment Video

Updated: Nov 19, 2025

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

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Altered functional network connectivity and working memory dysfunction in adolescents with epilepsy.

Jennifer Vannest1,2, Rupa Radhakrishnan3, Ana M Gutierrez-Colina4,5

  • 1Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA. jennifer.vannest@uc.edu.

Brain Imaging and Behavior
|February 2, 2021
PubMed
Summary
This summary is machine-generated.

Adolescents with epilepsy show working memory deficits and altered brain connectivity, impacting academic potential. These findings highlight differences in neural substrates compared to typically developing peers.

Keywords:
Adolescents with epilepsyCingulo-Opercular networkFunctional connectivityN-back taskWorking memory

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Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Epilepsy Research

Background:

  • Adolescents with epilepsy often experience working memory impairments.
  • These deficits can negatively affect learning and academic achievement.
  • Understanding the neural basis of these working memory issues is crucial.

Purpose of the Study:

  • To investigate working memory function in adolescents with epilepsy using functional magnetic resonance imaging (fMRI).
  • To compare brain activation and functional connectivity during a working memory task between adolescents with epilepsy and healthy controls.
  • To identify specific brain networks involved in working memory deficits in epilepsy.

Main Methods:

  • Recruited 29 adolescents (13-17 years) with non-lesional epilepsy and 20 healthy controls.
  • Administered an N-back fMRI task and neuropsychological tests.
  • Analyzed fMRI data using general linear models and assessed functional connectivity in predefined brain networks.

Main Results:

  • Adolescents with epilepsy performed significantly worse on working memory tests.
  • No significant differences in brain activation were observed during the N-back task between groups.
  • Reduced functional connectivity was found in the cingulo-opercular network (left frontal operculum and anterior cingulate gyrus) in adolescents with epilepsy.

Conclusions:

  • Adolescents with epilepsy exhibit working memory deficits and altered functional connectivity in key brain networks.
  • The neural substrates supporting working memory may differ in adolescents with epilepsy.
  • Further research is needed to elucidate the causes of poorer working memory performance in this population.