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Updated: Nov 19, 2025
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Emergence of myasthenia gravis in dengue infection-first case report
Yue Hui Lau1, Suganthi Chinnasami2
1Department of Neurology, Hospital Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, 23, Jalan Pahang, 50586, Kuala Lumpur, Malaysia. andrealau38@gmail.com.
Abstract:
The association of dengue infection (DI) with atypical neurological manifestations was first reported in 1976. DENV-2 and DENV-3 serotypes are mostly related to neurological problems. DI has shown an overall risk of 21 autoimmune diseases, and 4% may develop neuromuscular complications. The pathogenetic mechanisms behind myasthenia gravis (MG) occurring during DI is thought to be linked to the neurotrophic effect of the infection. We report a unique case of DENV-1 infection presenting with bilateral ptosis and dysphagia in a previously healthy adult.
Insights
Dengue infection can cause rare neurological issues like myasthenia gravis. This case highlights dengue virus type 1 (DENV-1) presenting with ptosis and dysphagia in an adult.
Area of Science:
- Neurology
- Infectious Diseases
- Immunology
Background:
- Dengue infection (DI) has been linked to atypical neurological manifestations since 1976.
- Dengue virus serotypes 2 and 3 (DENV-2, DENV-3) are frequently associated with neurological complications.
- DI increases the risk of 21 autoimmune diseases, with 4% developing neuromuscular issues.
Observation:
- A previously healthy adult presented with bilateral ptosis and dysphagia.
- The patient was diagnosed with dengue virus type 1 (DENV-1) infection.
Findings:
- This case represents a unique presentation of DENV-1 infection.
- The observed symptoms suggest a potential link between DENV-1 and neuromuscular complications like myasthenia gravis.
Implications:
- Understanding the neurotropic effects of dengue virus is crucial for diagnosing and managing neurological complications.
- Further research into the pathogenetic mechanisms of dengue-associated myasthenia gravis is warranted.
- This case broadens the spectrum of neurological presentations associated with dengue virus infection.
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