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Standardization for obtaining blood viscosity: A systematic review.
Marcel Valério de Arruda1, Alana Cruz Silva1, José Carlos Fernandes Galduróz2
1Programa de Pós Graduação em Neurociência e Cognição, Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, Santo Andre, Brazil.
European Journal of Haematology
|February 2, 2021
Summary
Standardizing blood viscosity (BV) measurement is crucial for understanding its role in disease. Key factors include prompt sample acquisition, appropriate storage temperatures, and specific shear rates for accurate in vivo representation.
Area of Science:
- Hemodynamics
- Biophysics
- Clinical Pathology
Background:
- Blood viscosity (BV) is implicated in various pathological processes.
- Standardization of BV measurement techniques is needed.
Purpose of the Study:
- To review and evaluate methods for acquiring blood viscosity.
- To identify critical parameters for standardizing BV measurements.
Main Methods:
- Systematic review of 50 articles on BV acquisition methods.
- Analysis of factors including sample storage, acquisition parameters, and equipment.
Main Results:
- Prompt sample acquisition and refrigeration at 4°C for extended storage are recommended.
- Acquisition at 37°C best reflects in vivo conditions.
- Shear rates between 0.1 and 1000 s⁻¹ are essential for understanding BV.
Conclusions:
- Standardized BV measurement protocols are necessary for reliable clinical interpretation.
- Optimal conditions include immediate measurement or refrigerated storage, physiological temperature acquisition, and defined shear rates.
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