Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parametric Survival Analysis: Weibull and Exponential Methods01:14

Parametric Survival Analysis: Weibull and Exponential Methods

827
Parametric survival analysis models survival data by assuming a specific probability distribution for the time until an event occurs. The Weibull and exponential distributions are two of the most commonly used methods in this context, due to their versatility and relatively straightforward application.
Weibull Distribution
The Weibull distribution is a flexible model used in parametric survival analysis. It can handle both increasing and decreasing hazard rates, depending on its shape parameter...
827
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

166
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
166
Assumptions of Survival Analysis01:15

Assumptions of Survival Analysis

252
Survival models analyze the time until one or more events occur, such as death in biological organisms or failure in mechanical systems. These models are widely used across fields like medicine, biology, engineering, and public health to study time-to-event phenomena. To ensure accurate results, survival analysis relies on key assumptions and careful study design.
252
Clearance Models: Noncompartmental Models01:17

Clearance Models: Noncompartmental Models

138
Clearance is a pharmacokinetic parameter traditionally defined by compartment models, signifying the rate at which a drug is expelled from the body. However, a noncompartmental model offers an alternative method for assessing clearance, primarily employing empirical data obtained after administering a single drug dose.
The noncompartmental approach capitalizes on extensive sampling data, correlating the volume of distribution to systemic exposure and the administered dosage. This method enables...
138
Distributions to Estimate Population Parameter01:26

Distributions to Estimate Population Parameter

4.8K
The accurate values of population parameters such as population proportion, population mean, and population standard deviation (or variance) are usually unknown. These are fixed values that can only be estimated from the data collected from the samples. The estimates of each of these parameters are sample proportion, the sample mean, and sample standard deviation (or variance). To obtain the values of these sample statistics, data are required that have particular distribution and central...
4.8K
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

218
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
218

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A comparison of multivariate and univariate meta-analysis.

Behavior research methods·2026
Same author

The Wor2 phenotypic switching regulator controls biofilm formation in Candida auris.

NPJ biofilms and microbiomes·2026
Same author

Global emergence and rapid spread of <i>Candidozyma auris</i> (syn. <i>Candida auris</i>): epidemiology, biology, and antifungal resistance.

Clinical microbiology reviews·2026
Same author

Genetic landscape and functional exploration of kidney cancer predisposition in cross-ancestral populations.

Nature communications·2026
Same author

Modeling cyclic patterns using a two-stage hybrid Bayesian approach.

Psychological methods·2026
Same author

Predicting relationship quality with itself? A single general factor captures most of the variance across 34 common relationship measures.

PloS one·2026
Same journal

Bayesian Machine Learning Tools for Alcohol Use Disorder Research: The bpaup R Package.

Multivariate behavioral research·2026
Same journal

A Unified Framework for Jointly modelling Response Times and Item Position Effects in Computer-Based Learning Assessments.

Multivariate behavioral research·2026
Same journal

Generalizability Theory Applied to Daily Relationship Quality: Substantive and Statistical Directions.

Multivariate behavioral research·2026
Same journal

A Modularized Higher-Order Diagnostic Classification Model for Clustered Attribute Hierarchies.

Multivariate behavioral research·2026
Same journal

Generalizing Causal Effects to a Target Population Without Individual-Level Data from the Target Population.

Multivariate behavioral research·2026
Same journal

betaselectr: Selective (and Proper) Standardization in Structural Equation Models.

Multivariate behavioral research·2026
See all related articles

Related Experiment Video

Updated: Nov 19, 2025

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.6K

A Bayesian Latent Variable Selection Model for Nonignorable Missingness.

Han Du1, Craig Enders1, Brian Tinnell Keller2

  • 1Department of Psychology, University of California.

Multivariate Behavioral Research
|February 2, 2021
PubMed
Summary
This summary is machine-generated.

A new Bayesian latent variable selection model (BLVSM) effectively imputes missing data, even with complex relationships. This method handles missing not at random (MNAR) data, outperforming traditional approaches, especially with large sample sizes.

Keywords:
Bayesian statisticsMissing not at randommultiple imputation

More Related Videos

An R-Based Landscape Validation of a Competing Risk Model
05:37

An R-Based Landscape Validation of a Competing Risk Model

Published on: September 16, 2022

2.3K
Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment
06:48

Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment

Published on: June 25, 2019

9.5K

Related Experiment Videos

Last Updated: Nov 19, 2025

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.6K
An R-Based Landscape Validation of a Competing Risk Model
05:37

An R-Based Landscape Validation of a Competing Risk Model

Published on: September 16, 2022

2.3K
Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment
06:48

Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment

Published on: June 25, 2019

9.5K

Area of Science:

  • Statistics
  • Data Science
  • Behavioral Sciences

Background:

  • Missing data are prevalent in educational, social, and behavioral sciences.
  • Missing Not At Random (MNAR) mechanisms, where missingness relates to unobserved data, pose significant challenges.
  • Existing MNAR methods often result in incomplete data and struggle with complex covariate structures (interactions, non-linear terms, random slopes).

Purpose of the Study:

  • To propose a novel Bayesian latent variable imputation approach for handling missing data, including MNAR mechanisms.
  • To simultaneously estimate the model of substantive interest alongside data imputation.
  • To address limitations of existing methods by accommodating complex covariate structures.

Main Methods:

  • Developed a Bayesian latent variable imputation approach.
  • Simultaneously estimated the imputation model and the substantive model.
  • The proposed Bayesian Latent Variable Selection Model (BLVSM) was evaluated through computer simulations.

Main Results:

  • BLVSM demonstrated effectiveness in imputing data with MNAR mechanisms, yielding results comparable to complete data analysis in most scenarios.
  • Performance was particularly strong with large sample sizes.
  • Compared to methods assuming Missing At Random (MAR), BLVSM provided less biased estimates and better coverage under MNAR conditions.
  • Performance was less satisfactory under specific conditions with small sample sizes and high missingness proportions.

Conclusions:

  • The proposed BLVSM is a robust method for handling missing data, particularly MNAR, in complex datasets.
  • It offers an improvement over traditional MAR-based methods, providing more accurate estimates.
  • The method is practical for real-world applications and available in the Blimp software.