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The role of miR-29 family in disease

Masahiro Horita1, Colin Farquharson1, Louise A Stephen1

  • 1The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Midlothian, Scotland, UK.

Journal of Cellular Biochemistry
|February 2, 2021
PubMed

Insights

The miR-29 family of microRNAs plays a key role in various diseases. Targeting these microRNAs shows therapeutic potential for conditions like osteoarthritis and immune disorders.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) are small noncoding RNAs regulating gene expression posttranscriptionally.
  • The miR-29 family (miR-29a, miR-29b, miR-29c) is implicated in diverse biological processes.
  • Dysregulation of miR-29 family members is linked to various pathological conditions.

Purpose of the Study:

  • To review the differential expression and functions of the miR-29 family in disease.
  • To explore the therapeutic potential of targeting miR-29 family members in specific diseases.
  • To summarize the roles of miR-29s in osteoarthritis, osteoporosis, cardiorenal, and immune diseases.

Main Methods:

  • Literature review of studies on miR-29 family expression and function.
  • Analysis of miR-29 family's role in disease pathogenesis.
  • Evaluation of therapeutic strategies targeting miR-29s.

Main Results:

  • miR-29s promote osteoblast differentiation and apoptosis.
  • miR-29s suppress chondrogenic and osteoclast differentiation, fibrosis, and T cell differentiation.
  • Abnormal miR-29 expression is associated with osteoarthritis, osteoporosis, cardiorenal, and immune diseases.

Conclusions:

  • The miR-29 family exhibits complex regulatory roles in various diseases.
  • Targeting the miR-29 family presents promising therapeutic avenues for multiple conditions.
  • Further research is needed to elucidate precise mechanisms and therapeutic applications.
Keywords:
cardiorenal diseaseimmune diseasemiRNA-29microRNAosteoarthritisosteoporosis

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