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Age-dependent differences in cholinergic drug response in two strains of mice
C Castellano1, A Oliverio, C Schwab
1Istituto di Psicobiologia e Psicofarmacologia del CNR, Rome, Italy.
Neuroscience Letters
|February 3, 1988
Abstract:
The behavioral effects of nicotine and oxotremorine were assessed in two strains of mice, C57BL/6 (C57) and DBA/2 (DBA), differing in the ontogeny of forebrain cholinergic structures. Both nicotine and oxotremorine depressed to a higher extent the behavior of DBA mice starting at day 45 of postnatal life.