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A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
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A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria

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Effects of gut microbiota on atherosclerosis through hydrogen sulfide

Dan-Dan Gui1, Wen Luo1, Bin-Jie Yan1

  • 1Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, 421001, China.

European Journal of Pharmacology
|February 2, 2021
PubMed

Insights

Gut microbiota imbalances may drive atherosclerosis via hydrogen sulfide (H2S) production. This review explores H2S as a novel therapeutic target for cardiovascular disease, focusing on atherosclerosis development.

Area of Science:

  • Cardiovascular Science
  • Microbiome Research
  • Gastroenterology

Background:

  • Cardiovascular diseases are a leading global cause of death.
  • Atherosclerotic cardiovascular disease (ASCVD) results from genetic and environmental factors.
  • Gut microbiota dysbiosis is linked to various health issues, including extraintestinal conditions.

Purpose of the Study:

  • To explore the role of gut microbiota in atherosclerosis development.
  • To investigate hydrogen sulfide (H2S) production by gut bacteria as a factor in atherosclerosis.
  • To identify H2S as a potential therapeutic target for atherosclerosis.

Main Methods:

  • Literature review on gut microbiota, H2S, and atherosclerosis.
  • Analysis of existing research on the cardiovascular functions of H2S.
  • Synthesis of evidence linking gut microbial H2S production to ASCVD pathogenesis.

Main Results:

  • Hydrogen sulfide (H2S) is a key gasotransmitter with significant cardiovascular roles.
  • H2S regulates blood pressure, angiogenesis, and cellular processes in the cardiovascular system.
  • Gut microbiota alterations can influence H2S levels, potentially impacting atherosclerosis.

Conclusions:

  • Gut microbiota may contribute to atherosclerosis through altered H2S production.
  • Targeting microbial H2S offers a novel therapeutic avenue for managing atherosclerosis.
  • Further research into the gut-cardiovascular axis and H2S is warranted.

Keywords:
AtherosclerosisGut microbiotaHydrogen sulfideInflammation

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