Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

10.5K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
10.5K
Preclinical Development: Overview01:28

Preclinical Development: Overview

5.5K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
5.5K
Prodrugs01:30

Prodrugs

3.6K
Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
Prodrugs help overcome...
3.6K
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

74
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
74
Clinical Trials: Overview01:11

Clinical Trials: Overview

4.3K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.3K
Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

967
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
967

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dmpic as an Orthogonal Protecting Group for Aspartic Acid Side Chains: Facilitating the Synthesis of Lactam-Cyclized Peptides.

The Journal of organic chemistry·2026
Same author

Multi-modal graph neural networks with cross-view attention and contrastive learning for molecular property prediction.

Computer methods in biomechanics and biomedical engineering·2026
Same author

Heparin microarray-based specific interaction assay of marine sulfated polysaccharides with antithrombin â…¢.

Communications chemistry·2026
Same author

Fourier-Enhanced Kolmogorov-Arnold Network With Attention for Drug-Target Interaction Prediction.

IEEE transactions on computational biology and bioinformatics·2026
Same author

Enhancing the reliability of skin tone evaluation: A study of full-face imaging devices with colour calibration.

International journal of cosmetic science·2026
Same author

Deep contrastive learning method for drug-target interactions prediction.

Computer methods in biomechanics and biomedical engineering·2026

Related Experiment Video

Updated: Nov 19, 2025

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
14:37

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles

Published on: July 6, 2012

11.7K

Recent progress and advanced technology in carbohydrate-based drug development.

Lin Pan1, Chao Cai2, Chanjuan Liu1

  • 1Key Laboratory of Marine Drugs of Ministry of Education, Shandong Provincial Key Laboratory of Glycoscience and Glycotechnology, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.

Current Opinion in Biotechnology
|February 2, 2021
PubMed
Summary
This summary is machine-generated.

Carbohydrate-based drug development (CBDD) has advanced significantly over two decades. Emerging technologies are accelerating the discovery of novel carbohydrate drugs for pharmaceutical applications.

More Related Videos

One-pot Microwave-assisted Conversion of Anomeric Nitrate-esters to Trichloroacetimidates
06:00

One-pot Microwave-assisted Conversion of Anomeric Nitrate-esters to Trichloroacetimidates

Published on: January 15, 2018

7.7K
Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
09:56

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis

Published on: September 6, 2019

7.0K

Related Experiment Videos

Last Updated: Nov 19, 2025

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
14:37

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles

Published on: July 6, 2012

11.7K
One-pot Microwave-assisted Conversion of Anomeric Nitrate-esters to Trichloroacetimidates
06:00

One-pot Microwave-assisted Conversion of Anomeric Nitrate-esters to Trichloroacetimidates

Published on: January 15, 2018

7.7K
Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
09:56

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis

Published on: September 6, 2019

7.0K

Area of Science:

  • Biochemistry and Pharmaceutical Sciences
  • Focuses on the critical roles and pharmaceutical potential of carbohydrates.

Background:

  • Carbohydrates are abundant biomolecules essential for numerous biological functions.
  • They hold significant untapped potential for pharmaceutical applications.

Purpose of the Study:

  • To provide an overview of carbohydrate-based drug development (CBDD) over the past 20 years.
  • To highlight emerging techniques and their impact on accelerating CBDD.

Main Methods:

  • Enzymatic synthesis
  • Metabolic engineering
  • Site-specific glycoconjugation
  • Carbohydrate libraries and microarrays
  • Carbohydrate-gut microbiome evaluation

Main Results:

  • Advanced techniques have dramatically accelerated the pace of CBDD.
  • Recent drug approvals and emerging technologies showcase progress in the field.

Conclusions:

  • Emerging technologies offer new opportunities for discovering novel carbohydrate drugs.
  • The field of CBDD is rapidly evolving with significant therapeutic potential.