Related Experiment Video

Updated: Nov 19, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.6K

The Association between Presence of Comorbidities and COVID-19 Severity: A Systematic Review and Meta-Analysis

Maryam Honardoost1,2, Laila Janani3, Rokhsareh Aghili1

  • 1Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.

Cerebrovascular Diseases (Basel, Switzerland)
|February 2, 2021
PubMed

Insights

Comorbidities significantly increase COVID-19 severity. Cerebrovascular disease, cardiovascular disease, and chronic lung disease showed the strongest associations with severe COVID-19 outcomes.

Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Public Health

Background:

  • Several studies suggest a link between severe COVID-19 and comorbidities, but a comprehensive analysis is lacking.
  • Understanding these associations is crucial for risk stratification and patient management during pandemics.

Approach:

  • This meta-analysis systematically evaluated the association between various comorbidities and COVID-19 infection severity.
  • Data from 28 studies involving 6,270 individuals were analyzed using fixed-effects or random-effects models.

Key Points:

  • Comorbidities were present in approximately 41% of COVID-19 patients.
  • The strongest association with severe COVID-19 was observed for cerebrovascular disease (OR 4.85).
  • Other significant comorbidities included cardiovascular disease (OR 4.81), chronic lung disease (OR 4.19), cancer (OR 3.18), diabetes (OR 2.61), and hypertension (OR 2.37).

Conclusions:

  • The presence of comorbidities is significantly associated with increased COVID-19 severity.
  • Cerebrovascular disease, cardiovascular disease, and chronic lung disease represent the highest risk factors for severe COVID-19.
  • These findings highlight the importance of managing underlying health conditions to mitigate COVID-19 complications.
Abstract

Keywords:
COVID-19Cardiovascular disordersCerebrovasular diseaseComorbid conditionsDisease severity

More Related Videos

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

14.9K
Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-1906:29

Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19

Published on: May 25, 2022

2.6K

Related Concept Videos

COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.6K
Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
4.8K
Bias in Epidemiological Studies01:29

Bias in Epidemiological Studies

Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:  
969
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.2K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.8K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.7K