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Nivolumab plus regorafenib in patients with small bowel adenocarcinoma: A case report

Gairong Zhang1, Li Lin2, Dapeng Dong1

  • 1Department of Oncology, Beijing Huian Hospital of Integrated TCM and Western Medicine.

Medicine
|February 3, 2021
PubMed
Abstract

Insights

This case study shows that combining nivolumab and regorafenib may effectively treat advanced small bowel adenocarcinoma (SBA). This combination therapy provided 15 months of disease control and symptom improvement in a patient with stage IV disease.

Area of Science:

  • Oncology
  • Gastroenterology
  • Immunotherapy

Background:

  • Small bowel adenocarcinomas (SBAs) are rare gastrointestinal cancers with limited treatment options for advanced stages.
  • Surgery is the only potentially curative option for localized SBAs.

Observation:

  • A 39-year-old woman presented with symptoms of duodenal obstruction due to a large mass.
  • Diagnosis was stage IV duodenum adenocarcinoma with metastasis to the right adnexal region.

Findings:

  • The patient received nivolumab (immune checkpoint inhibitor) plus regorafenib after failing multiple lines of therapy.
  • This combination achieved 15 months of disease control with significant symptom improvement.

Implications:

  • This is the first reported case of advanced SBA treated with nivolumab and regorafenib.
  • The findings suggest this combination therapy holds potential for treating advanced small bowel adenocarcinomas.

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