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Updated: Nov 19, 2025

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Advanced breast cancer with cachexia: A case report.

Nan Liu¹, Shuting Li¹, Junmei Jia¹

¹Department of Oncology.

|February 3, 2021

Summary

This summary is machine-generated.

Cachexia, a cancer-related syndrome, was documented in a breast cancer patient. Monitoring abdominal muscle wasting may predict cachexia and metastatic disease extent in these patients.

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Area of Science:

Oncology
Radiology
Medical Imaging

Background:

Cachexia is a significant cancer syndrome impacting treatment tolerance, quality of life, and survival.
It is most common in pancreatic, gastric, colorectal, lung, and head and neck cancers.
Cachexia is infrequently documented in breast cancer patients.

Observation:

A 46-year-old woman with invasive ductal carcinoma developed cachexia with bone, lung, and lymph node metastases.
Over two years, she experienced significant weight loss (16%) and required hospitalization for various symptoms.
Image analysis revealed a correlation between abdominal muscle area and metastatic tumor burden.

Findings:

A strong negative correlation was observed between abdominal muscle area and metastatic tumor area at the L2 vertebral level.
Abdominal muscle wasting was identified as a potential marker for cachexia and metastatic disease extent.
Computational tomography (CT) quantification provided early indicators of cachexia in metastatic breast cancer.

Implications:

Monitoring abdominal muscle wasting may serve as a prognostic factor for cachexia in metastatic breast cancer.
CT-based quantification can aid clinicians in assessing cachexia extent.
This approach may improve early detection and management of cachexia in breast cancer patients with bone metastasis.