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Relationship between A1166C polymorphism of angiotensin II type 1 receptor gene and arteriosclerosis: A protocol for

Zhongping Shi1, Jun Wang, Shanjiang Chen

  • 1Wenzhou Central Hospital, Wenzhou, Zhejiang Province, China.

Medicine
|February 3, 2021
PubMed

Insights

This study systematically evaluates the association between the angiotensin II type 1 receptor (AT1R) gene A1166C polymorphism and arteriosclerosis. Findings will clarify the genetic basis of arteriosclerosis, aiding in understanding its hereditary nature.

Area of Science:

  • Genetics
  • Cardiovascular Disease
  • Molecular Biology

Background:

  • Arteriosclerosis exhibits a genetic correlation, with the angiotensin II type 1 receptor (AT1R) gene A1166C polymorphism frequently linked to the condition.
  • Existing evidence for this association lacks a robust evidence-based foundation.
  • This systematic review aims to consolidate and evaluate the existing data.

Purpose of the Study:

  • To systematically evaluate the relationship between the AT1R gene A1166C polymorphism and arteriosclerosis.
  • To provide an evidence-based foundation for understanding the genetic predisposition to arteriosclerosis.

Main Methods:

  • A comprehensive literature search was conducted across multiple databases (CNKI, Wanfang, VIP, CBM, PubMed, EMBASE, Web of Science, Cochrane Library) up to December 2020.
  • Included observational studies (case-control, cross-sectional, cohort) in English and Chinese were assessed for quality by two independent researchers.
  • Statistical analysis was performed using Stata 16.0 software.

Main Results:

  • Pulse wave velocity will be utilized as a key indicator for assessing arteriosclerosis.
  • The study will analyze the correlation between the AT1R gene A1166C polymorphism and arteriosclerosis using collected data.

Conclusions:

  • This systematic review will offer evidence-based insights into the genetic factors contributing to arteriosclerosis.
  • The findings are expected to enhance the understanding of the hereditary components of arteriosclerosis.
Abstract

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