Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

High-avidity TCR signaling induces a distinct KLR-positive exhaustion state in human tumor-infiltrating CD8 T cells associated with immunotherapy response.

bioRxiv : the preprint server for biology·2026

Same author

Ectopic integrin β1 overproduction by squamous carcinoma cells contributes to immune evasion-associated metastasis.

Cancer letters·2026

Same author

Radiation as an immune modulator: mechanisms and implications for combination with immunotherapy.

Nature reviews. Cancer·2026

Same author

Durvalumab With or Without Tremelimumab in Combination With Chemoradiotherapy in Patients With Limited-Stage SCLC: Results from the Phase 1 CLOVER Study.

JTO clinical and research reports·2025

Same author

IL15/IL15Rα Complex Induces an Antitumor Immune Response following Radiotherapy only in the Absence of Tregs and Fails to Expand Progenitor TCF1+ CD8 T Cells.

Molecular cancer therapeutics·2025

Same author

Establishing an integrated approach to head and neck cancer treatment and prevention: The Robert Ebert and Greg Stubblefield Head and Neck Tumor Center Model.

Oral oncology·2025

Same journal

Correction: Kang et al. Energy-Saving Electrospinning with a Concentric Teflon-Core Rod Spinneret to Create Medicated Nanofibers. <i>Polymers</i> 2020, <i>12</i>, 2421.

Polymers·2026

Same journal

Influence of Self-Adhesive Resin Composite Deep Marginal Elevation on the Sealing Ability of CAD/CAM Lithium Disilicate Glass-Ceramic Inlays: An In Vitro Study.

Polymers·2026

Same journal

Modulating Exciton Dynamics Through Fluorescent Side Group Incorporation in Benzodithiophene-Benzotriazole-Isoindigo Terpolymers.

Polymers·2026

Same journal

PLA/PBSA Biocomposites Reinforced with Tangerine Tree-Derived Agro-Industrial Waste for Rigid Packaging: Effect of Extraction Treatment on Morphology and Thermo-Mechanical Performance.

Polymers·2026

Same journal

Synergistic Coatings Based on Chitosan and <i>Eugenia caryophyllata</i> Essential Oil to Improve Postharvest Quality of <i>Capsicum chinense</i>.

Polymers·2026

Same journal

Bioethanol from <i>Miscanthus</i> × <i>giganteus</i>: A Comparative Study of Different Pretreatment Technologies.

Polymers·2026

See all related articles

Search research articles

Home
Light-responsive Polymeric Micellar Nanoparticles With Enhanced Formulation Stability.

Home
Light-responsive Polymeric Micellar Nanoparticles With Enhanced Formulation Stability.

Related Experiment Video

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Light-Responsive Polymeric Micellar Nanoparticles with Enhanced Formulation Stability.

Kyoung Nan Kim¹, Keun Sang Oh², Jiwook Shim³

¹Department of Chemistry, University of Colorado Denver, Denver, CO 80204, USA.

|February 3, 2021

View abstract on PubMed

Summary

This summary is machine-generated.

We created light-sensitive nanoparticles that release the anti-cancer drug doxetaxel (DTX) when exposed to UV light. These stable nanoparticles show enhanced cancer cell killing, improving drug delivery potential.

Keywords:

controlled release drug delivery light-sensitive polymer polymeric micellar nanoparticles stimuli-responsive drug delivery

More Related Videos

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst

Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst

Published on: June 8, 2016

Related Experiment Videos

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst

Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst

Published on: June 8, 2016

Area of Science:

Biomaterials Science
Nanotechnology
Drug Delivery

Background:

Light-sensitive polymeric micelles offer controlled drug release for targeted therapies.
Developing stable nanoparticles with tunable release mechanisms is crucial for effective cancer treatment.

Purpose of the Study:

To develop diazonaphthoquinone (DNQ)-conjugated micellar nanoparticles for UV-triggered release of doxetaxel (DTX).
To evaluate the stability and in vitro efficacy of these light-sensitive nanoparticles for cancer therapy.

Main Methods:

Synthesis of DNQ-conjugated polymeric micelles encapsulating DTX.
Assessment of micellar stability in bovine serum albumin (BSA) solution.
Evaluation of cytotoxicity of DTX-loaded micelles on cancer cells upon UV irradiation.

Main Results:

DNQ-conjugated micelles demonstrated a hydrophobic-to-hydrophilic core transition under UV light, enabling DTX release.
The nanoparticles exhibited low critical micelle concentration and high stability due to hydrophobic and π-π stacking interactions.
Irradiation significantly enhanced the cytotoxicity of DTX-loaded micellar nanoparticles against cancer cells.

Conclusions:

DNQ-conjugated micellar nanoparticles provide a robust platform for spatiotemporally controlled drug delivery.
Enhanced stability and triggered release improve therapeutic potential for cancer treatment by increasing drug efficacy and circulation time.