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USP2-Related Cellular Signaling and Consequent Pathophysiological Outcomes

Hiroshi Kitamura1, Mayuko Hashimoto1

  • 1Laboratory of Veterinary Physiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan.

International Journal of Molecular Sciences
|February 3, 2021
PubMed

Insights

Ubiquitin specific protease 2 (USP2) is a deubiquitinating enzyme impacting cell cycle, carcinogenesis, and circadian rhythms. USP2 variants affect metabolism, immune responses, and ion channel expression, influencing various physiological processes.

Area of Science:

  • Biochemistry and Molecular Biology
  • Cellular Biology
  • Physiology

Background:

  • Ubiquitin specific protease 2 (USP2) is a deubiquitinating enzyme with diverse cellular functions.
  • USP2 plays roles in cell cycle regulation, carcinogenesis, and circadian rhythm.
  • USP2 influences metabolic pathways, immune responses, and ion channel expression.

Purpose of the Study:

  • To review the multifaceted roles of USP2 in cellular events.
  • To identify signaling molecules upstream and downstream of USP2.
  • To describe phenotypic differences in USP2 experimental models.

Main Methods:

  • Literature review of USP2 functions.
  • Analysis of USP2's impact on cell cycle regulators (cyclins, Aurora-A).
  • Examination of USP2's role in CLOCK/BMAL1 complex and metabolic pathways.

Main Results:

  • USP2 deubiquitinates cyclins and Aurora-A, affecting cell cycle and carcinogenesis.
  • USP2 targets tumorigenic molecules like EGF and fatty acid synthase, and inhibits p53 signaling.
  • USP2 variants impact hepatic gluconeogenesis, cholesterol uptake, adipose inflammation, and insulin sensitivity.
  • USP2 influences cytokine production and signaling, and promotes ion channel surface expression.
  • Usp2 knockout mice show altered locomotion and male fertility.

Conclusions:

  • USP2 is a critical regulator of cell cycle, carcinogenesis, and circadian rhythms.
  • USP2 significantly impacts metabolic homeostasis and immune function.
  • USP2's diverse roles highlight its potential as a therapeutic target.
Keywords:
braincell cyclecircadian clockdeubiquitinationfertilityinflammationion balancemetabolic disordertumorigenesisubiquitin-specific protease

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