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Published on: February 19, 2017
Red cell distribution width is associated with all-cause mortality in patients with acute stroke: a retrospective
Han Zhao1, Yuanchen Zhao1, Zhipeng Wu1
1Department of Neurology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Zhejiang, Wenzhou, China.
Objectives:
This study aimed to evaluate the association between the red blood cell distribution width (RDW) and mortality in patients with stroke.
Methods:
We conducted a retrospective cohort study on patients with stroke in the Medical Information Mart for Intensive Care Database III. Cox proportional hazards regression models were used to estimate hazard ratios of 30-day, 90-day, and 1-year mortality in relation to the RDW level.
Results:
A total of 4134 patients were enrolled, including 2646 patients with ischemic stroke and 1668 with hemorrhagic stroke. After adjustment for potential confounders, the hazard ratio (95% confidence interval) of 30-day mortality for the second (RDW: 13.4%-14.3%) and third (>14.3%) tertiles was 1.15 (0.96, 1.37) and 1.40 (1.17, 1.68), respectively, compared with the reference group (<13.4%). A two-piecewise linear regression model was established and the inflection point of RDW was 16.7%. When RDW was >16.7%, an increase in RDW did not increase stroke mortality.
Conclusions:
The RDW is a prognostic factor of patients with stroke. This finding needs to be confirmed in future prospective studies.
