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Dynamics of Toll-like Receptors Signaling in Skeletal Muscle Atrophy

Aarti Yadav1, Anil Dahuja2, Rajesh Dabur1

  • 1Clinical Research Laboratory, Department of Biochemistry, Maharshi Dayanand University, Rohtak-124001, Haryana, India.

Current Medicinal Chemistry
|February 3, 2021
PubMed

Insights

Toll-like receptors (TLR) signaling drives skeletal muscle atrophy by promoting inflammation and protein breakdown. Inhibiting TLR pathways may offer a therapeutic strategy for muscle wasting conditions.

Area of Science:

  • Molecular Biology
  • Physiology
  • Immunology

Background:

  • Skeletal muscle atrophy involves inflammation and oxidative stress, increasing protein breakdown.
  • Toll-like receptors (TLR) signaling pathways are implicated in regulating muscle mass.
  • Activated TLR signaling can inhibit muscle growth and promote atrophy.

Purpose of the Study:

  • To review the role of TLR signaling in muscle loss.
  • To explore the connection between inflammation and skeletal muscle growth.

Main Methods:

  • Literature review of studies on TLR signaling in skeletal muscle.
  • Analysis of molecular mechanisms linking TLRs, inflammation, and muscle catabolism.

Main Results:

  • TLR2 and TLR4 activation exacerbates pro-inflammatory cytokine release.
  • Activated TLR signaling inhibits muscle mass maintenance.
  • Inflammation driven by TLRs disrupts normal muscle programming.

Conclusions:

  • TLR signaling is a key mediator of skeletal muscle atrophy.
  • Targeting TLR pathways could be a potential therapeutic approach for muscle wasting.
Keywords:
Toll-like receptorsinflammationoxidative stresspro-inflammatory cytokines.skeletal muscle atrophy

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