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Epilepsy and Seizures: Overview

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...

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Updated: Nov 19, 2025

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

Resistant Temporal Lobe Epilepsy: Initial Steps into a Bigger Epilepsy Surgery Program.

Anant Mehrotra¹, Suyash Singh¹, Soumen Kanjilal¹

¹Department of Neurosurgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Journal of Neurosciences in Rural Practice

|February 3, 2021

Summary

This summary is machine-generated.

Drug-resistant epilepsy patients with temporal lobe epilepsy (TLE) can achieve seizure freedom through surgery. This study shows encouraging surgical outcomes in a resource-limited setting, reducing medication needs and improving patient care.

Keywords:

anterior-medial temporal lobe resection drug-resistant epilepsy international league against epilepsy temporal lobe epilepsy

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Published on: June 13, 2016

Area of Science:

Neurology
Neurosurgery
Epileptology

Background:

Drug-resistant epilepsy often involves focal impaired seizures originating in the temporal lobe (TLE).
Surgical interventions like anterior-medial temporal lobe resection are common for TLE.
India faces a shortage of specialized epilepsy care centers, particularly in populous states.

Purpose of the Study:

To report the single-center, observational, retrospective experience of treating TLE in a resource-limited environment.
To evaluate the efficacy and outcomes of surgical interventions for TLE in this context.

Main Methods:

Retrospective analysis of medically refractory epilepsy patients from 2016-2019.
Patient selection based on a noninvasive protocol including clinical semiology, scalp electroencephalography (EEG), long-term video EEG monitoring, and magnetic resonance imaging (MRI).
Follow-up via outpatient records or telephone, assessed using the International League Against Epilepsy score.

Main Results:

23 TLE cases analyzed: 7 with mesial temporal sclerosis, 16 with lesions (cavernomas, tumors, AVMs).
18 out of 23 patients achieved seizure freedom after surgery (median follow-up: 19 months).
Significant reduction in antiepileptic drugs (AEDs) post-surgery (average from 2.9 to 1.2), with 5 patients fully off AEDs.

Conclusions:

A multidisciplinary and holistic approach is crucial for optimal patient care in TLE.
The initial surgical experience in this resource-limited setting yielded encouraging results for seizure control and medication reduction.