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Patterns of thromboembolic pulmonary vascular disease in COVID-19

Yousef Shahin1,2, Smitha Rajaram2, Vivak Parkash1

  • 1Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.

Pulmonary Circulation
|February 3, 2021
PubMed

Insights

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, or COVID-19, is linked to a higher risk of thrombosis. This study reveals pulmonary vascular disease patterns in COVID-19 patients, including acute pulmonary embolism and microvascular thrombosis.

Area of Science:

  • Cardiology
  • Pulmonology
  • Pathology

Background:

  • COVID-19 is a respiratory illness caused by SARS-CoV-2.
  • Thrombosis is a known complication of COVID-19.

Purpose of the Study:

  • To investigate pulmonary vascular disease patterns in COVID-19 patients.
  • To identify evidence of both large vessel and microvascular thrombosis.

Main Methods:

  • Review of imaging studies in COVID-19 patients.
  • Analysis of perfusion defects and signs of pulmonary embolism.

Main Results:

  • Observed classical acute pulmonary embolism in some patients.
  • Identified subsegmental perfusion defects suggesting microvascular thrombosis in others, even without acute pulmonary embolism.

Conclusions:

  • COVID-19 is associated with diverse patterns of pulmonary vascular disease.
  • Microvascular thrombosis is a potential mechanism for lung injury in COVID-19.

Keywords:
CT-LSIMcoronavirusiodine subtraction mappingmicrovascular thrombosispulmonary embolism

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