Related Experiment Video
Updated: Nov 19, 2025
High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue
Published on: September 30, 2022
Rapid-kilovoltage-switching dual-energy computed tomography (CT) for differentiating spinal osteolytic metastases
Yuan Yuan1, Ning Lang1, Huishu Yuan1
1Department of Radiology, Peking University Third Hospital, Beijing, China.
Background:
Rapid-kilovoltage-switching dual-energy computed tomography (RDECT) is a non-invasive, alternative technique for quantitative diagnosis. This study aimed to investigate the value of RDECT for differentiating spinal osteolytic metastases (SOM) from spinal infections (SIs).
Methods:
RDECT was performed on 29 patients with SOM and 18 patients with SIs. Both iodine-based and water-based material decomposition images were generated from the spectral CT scan. The iodine/water densities of lesions on iodine/water material-decomposition images and the CT attenuation values on traditional CT images were measured three times at different image levels, and the averages were calculated. The lesion-to-muscle ratio (LMR) and lesion-to-artery ratio (LAR) for iodine density measurements were calculated. All parameters were compared between the two groups using the two-tailed Student's t-test. A P value <0.05 was considered statistically significant. The sensitivity and specificity for differentiating SOM from SIs were determined using receiver operating characteristic curves (ROC).
Results:
Iodine density, LMR, and LAR during the arterial phase (AP) and venous phase (VP) were all significantly higher for SOM than for SIs (all P<0.05). The water densities and traditional CT attenuation values during the AP and VP were not significantly different between the two groups. For ROC analysis, LAR during the VP (LARVP) showed the best diagnostic performance, with an area under the ROC curve (AUC) value of 0.862. When the LARVP was 0.54, the sensitivity was 82.80% and the specificity was 77.80% for differentiating SOM from SIs.
Conclusions:
RDECT can provide additional information that may be useful for differentiating atypical SOM from SIs.
More Related Videos
18:40Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice
Published on: October 16, 2014
08:04Monitoring Tumor Metastases and Osteolytic Lesions with Bioluminescence and Micro CT Imaging
Published on: April 14, 2011
Related Concept Videos
01:24X-ray Imaging
01:14Imaging Studies I: CT and MRI
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
01:30Radiological Investigation II: MRI and Ventilation Perfusion Scan
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
01:30Radiological Investigation I: X-ray and CT
01:10Computed Tomography
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
01:27Imaging Studies III: Computed Tomography