The impact of changing to the Global Lung Function Initiative reference equations for transfer factor in paediatrics

The Global Lung Function Initiative (GLI) all-age reference equations for carbon monoxide transfer factor were published in 2017 and endorsed by the European Respiratory Society and American Thoracic Society. In order to understand the impact of these new reference equations on the interpretation of results in children referred from haematology and oncology paediatric services, we retrospectively analysed transfer factor results from any paediatric patient referred from haematology/oncology in the period 2010-2018. We examined transfer factor of the lung for carbon monoxide (T _LCO), transfer coefficient of the lung for carbon monoxide (K _CO) and alveolar volume (V _A) from 241 children (age range 7-18 years, 130 male). The predicted values from Rosenthal and GLI were plotted against height. The difference in interpretation of results was analysed by looking at the percentage of patients below the lower limit of normal for each parameter. Overall, the Rosenthal predicted values for T _LCO were higher than those predicted by GLI. Predicted K _CO using Rosenthal was higher in all observations. In contrast, the Rosenthal predicted V _A was generally lower than the GLI value. The GLI predicted values for transfer factor show considerable differences compared with currently used paediatric UK reference values, differences that will have a significant impact on interpretation of results.